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Dermatofibrosarcoma Protuberans and Dermatofibroma: Dermal Dendrocytomas: An Ultra-structural Study

Issue: Vol.6, No.1 - January 2007

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Article Type: Manuscript

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  1. Dr Hugo Dominguez-Malagon
    MD
    Department of Pathology, Instituto Nacional de Cancerologia
  2. Dr Ana Maria Cano-Valdez
    MD
    Department of Pathology, Instituto Nacional de Cancerologia

Dermatofibroma (DF) and Dermatofibrosarcoma Protuberans (DFSP) are dermal tumors whose histogenesis has not been well defined to date. The differential diagnosis in most cases is established in routine H/E sections and may be confirmed by immunohistochemistry; however there are atypical variants of DF with less clear histological differences and non-conclusive immunohistochemical results. In such cases electron microscopy studies may be useful to establish the diagnosis.

In the present paper the ultra-structural characteristics of 38 cases of DFSP and 10 cases of DF are described in detail, the objective was to identify some features potentially useful for differential diagnosis, and to identify the possible histogenesis of both neoplasms.

DFSP in all cases was formed by stellate or spindled cells with long, slender, ramified cell processes joined by primitive junctions, sub-plasmalemmal densities were frequently seen in the processes. Other common finding was the presence of Multi Vesicular Buds (MVB).

In contrast, DF is characterized by proliferation of capillary vessels with prominent endothelium and a perivascular population of plump spindled cells devoid of cell processes, these cells contained intra-cytoplasmic lipid droplets and rare sub-plasmalemmal densities but lacked MVB.

With the ultra-structural characteristics and the constant expression of CD34 in DFSP, a probable origin in dermal dendrocytes is postulated. The histogenesis of DF remains obscure.

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