Recent Trends in Nanotechnology: Potential Approach for Cancer Therapy
Issue: Vol.9, No.4 - October 2010
Article Type: Manuscript
Conventional chemotherapeutic drugs are distributed non-specifically in the body where they affect both cancerous and healthy cells, resulting in dose-related side effects and inadequate drug concentrations reaching the tumour. Nonspecific drug delivery leads to significant complications that represent a serious obstacle to effective anticancer therapy. In addition, the occurrence of resistance phenomena reduces the efficacy of cancer treatment. To overcome the lack of specificity of conventional chemotherapeutic drugs, several ligand-targeted therapeutic strategies, including immunotoxins, radioimmunotherapeutics, and drug immunoconjugates, are being developed. Although these conjugated agents have shown promising efficacy compared with conventional chemotherapy drugs, limitations in their delivery efficiency still remain. Recent progress in cancer nanotechnology raises exciting opportunities for specific drug delivery. Currently developed delivery systems for anticancer agents include colloidal systems polymer implants and polymer conjugates with marketed formulation also reported.
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- Profile: Prof. Tadeusz Robak MD, PhD
- Chemotherapy for Gastric Cancer: ?Who is an Asian Star??
- Pathological Consequences of VCP-Mutations on Human Striated Muscle
- The Involvement of Hypoxia-Inducible Factor- 1α in the Susceptibility to γ-rays and Chemotherapeutic Drugs of Oral Squamous Cell Carcinoma Cells
- Efficacy and Tolerability of Imatinib Mesylate In Advanced Gastrointestinal Stromal Tumors
- Is Adjuvant Radiotherapy Worth Giving in Surgically Resected Endometrial Cancer?
- Knowledge and Awareness of H1N1 Influenza Among At Risk Groups: A Study of Haemodialysis Patients