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Recent Trends in Nanotechnology: Potential Approach for Cancer Therapy

Issue: Vol.9, No.4 - October 2010

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Article Type: Manuscript

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  1. Dr Ganesh Shesrao Bangale
    M.Pharm, (PhD)
    Assistant Professor, Department of Pharmaceutics, Parul Institute of Pharmacy
  2. B. Stephen Rathinaraj
  3. K. S Rajesh
  4. Gajanan Shinde
  5. Deepak Umalkar
  6. P.S Sona

Conventional chemotherapeutic drugs are distributed non-specifically in the body where they affect both cancerous and healthy cells, resulting in dose-related side effects and inadequate drug concentrations reaching the tumour. Nonspecific drug delivery leads to significant complications that represent a serious obstacle to effective anticancer therapy. In addition, the occurrence of resistance phenomena reduces the efficacy of cancer treatment. To overcome the lack of specificity of conventional chemotherapeutic drugs, several ligand-targeted therapeutic strategies, including immunotoxins, radioimmunotherapeutics, and drug immunoconjugates, are being developed. Although these conjugated agents have shown promising efficacy compared with conventional chemotherapy drugs, limitations in their delivery efficiency still remain. Recent progress in cancer nanotechnology raises exciting opportunities for specific drug delivery. Currently developed delivery systems for anticancer agents include colloidal systems polymer implants and polymer conjugates with marketed formulation also reported.

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