Print

The Role of CCAAT/Enhancer Binding Proteins in Human Disease

Issue: Vol.3, No.4 - October 2004

« Back to Articles

Article Type: Manuscript

Download PDF Version »

  1. Dr Adrian F. Gombart
    Ph.D
    Cedars-Sinai Medical Center, Burns & Allen Research Institute,

Numerous invitro and invivo models implicate the CCAAT/enhancer binding protein (C/EBP) family as important regulators of cellular growth, differentiation and function. Conversely, the loss of their normal activity plays a role in the development of human disease. The first member of this family implicated in human diseases. The first member of this family implicated in human disease was C/EBP (CHOP/GADD153). Translocations involving this gene were described in myxoid liposarcomas. Recently, mutations in the C/EBPE gene were described in a human condition known as neutrophil specific granule deficiency (SGD). Most recently, 7-10% of acute myeloid leukemias possess mutations in the C/EBPA gene. This review will focus on the involvement of C/EBP family members in human disease.

Download PDF Version »

Favourites   Share / Bookmark

Also In This Issue

« Back to Articles