Prevalence and Associated Factors for Non-Resectable Lung Cancer at Presentation

Issue: Vol.9, No.1 - January 2010

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  1. Dr Che Wan A Hashim
    Senior Lecturer, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia
  2. Azza Omar
  3. Shaharudin Abdullah
  4. T Alina
  5. T Ismail

Background: Lung cancer is on the rise in many Asian countries. It has poor prognosis, with overall five-year survival figures varying between 5 and 10% worldwide. Our local data on lung cancer is limited. Therefore we conducted this study to know the prevalence and associated factors for non-resectable lung cancer at presentation in Hospital Universiti Sains, Malaysia. We also would like to know the patients blood profile at presentation and to determine the association of histology subtype with the cancer stage at presentation.

Method: This study was a retrospective review of all confirmed diagnosis of lung cancer in Hospital Universiti Sains, Malaysia from 1996 to 2007. Patients who fulfilled our selection criteria were included in the study.

Result: The total of 245 patients were included in this study. Forty-two patients (17.1%) were resectable (stage I, IIA, IIB and IIIA) and 203 patients (82.9%) were non resectable (stage IIIB and IV). The proportion of male was 65.3% and the mean age 60.3 1 11.6 years. The patients included in the study consisted of 78.8% Malays and 21.2% non-Malays. We found that patients with an increase in 1mmol/l se calcium and 1 unit serum LDH will have 5.12 times and 0.004 times odd of being non-resectable respectively. Adenocarcinoma has 2.17 times odds of being non-resectable at presentation compared to other histology subtype.

Conclusion: Serum calcium and serum lactate dehydrogenase (LDH) were two significant laboratory findings at presentation. Adenocarcinoma remained the most common histology findings in our study and significantly correlates to advanced cancer stage at presentation.

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